Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1707 | Thyroid (non-cancer) | ICEECE2012

Laminin and poly-laminin, a polymeric form of laminin assembled at acidic pH, differentially modulate PCCL3 thyroid cell behavior

Palmero C. , Barroso M. , Souza E. , Merlmestein C. , Takiya C. , Carvalho D. , Miranda-Alves L. , Nasciutti L.

The extracellular matrix protein laminin forms polymers both in vivo and in vitro. Acidification of pH leads to the formation of an artificial polymer with biomimetical properties, named poly-laminin (polyLM). Follicular cells in the thyroid are in close contact with laminin, but their response to this important extracellular signal is still poorly understood. Thyroid PCCL3 epithelial cells cultivated either on glass, regular laminin (LM) or laminin previously po...